Melissa and Samuel are fraternal twins, estranged from each other since college and re-united by the death of their mother. After their mother's funeral, at the wake, they are visited by a kindly gentleman, who identifies himself as a professional colleague of the obstetrician who delivered them. He is a clinical pathologist, and he reveals that they alone possess a genetic resistance to form of rare form of pulmonary disease which has been mysteriously ravaging the state of Florida. However, this resistance can only properly be studied in conditions most akin to the womb, as their lungs must be filled with oxygen-rich amniotic fluid.
Out of a sense of obligation towards their departed mother (a medical researcher herself), they agree to participate in a nine-month long experiment, living together in a synthetic womb, filled with amniotic fluid.
As Melissa and Samuel are both entertainment reporters, they make their living reporting from the red carpet of awards ceremonies and covering holiday parades. The Holy Father's mother succumbed to the disease herself, and, moved by the twins' sacrifice in the fight against this crippling disease, the Vatican has donated an old Popemobile, which will be modified to cradle the synthetic womb-orb, allowing them to perform their duties.
Driven together, the siblings must navigate the image-obsessed world of their professional career and their own long-lingering resentments towards each other... In a fake womb.